False sense of security. Many malware strains lie dormant for weeks or only activate under certain conditions (e.g., when you log into your bank).
There are a few legitimate open-source projects like "Microsoft Activation Scripts" (MAS) – but even those violate Microsoft's terms and carry risks. MAS from a verified author is less likely to include extra malware, but it's still piracy and still a security risk (any future update could be malicious). Conclusion "Descargar KMSPico 10.2.0 final portable github" is a search that leads almost inevitably to malware, identity theft, or ransomware. No legitimate software requires you to disable your antivirus, run an unknown executable, or trust anonymous uploaders on GitHub.
No. Cybercriminals use packers, crypters, and obfuscation to evade detection – at least temporarily. By the time your antivirus catches it, damage may already be done.